Immune Response to COVID-19 Vaccine in Multiple Sclerosis Patients Treated With Teriflunomide and Alemtuzumab

  • participants needed
  • sponsor
    Sheba Medical Center
Updated on 4 December 2022


Phase IV, 3-armed, prospective, open-label, single-center, Israeli study, examining the response to SARS-CoV-2 vaccination in 30 teriflunomide-, 10 alemtuzumab-treated patients, and 30 age-matched (for the teriflunomide group) untreated MS patients. Treatments will be administered according to common local practice. Demographic, clinical, treatment-related and COVID-19-related data will be collected. Blood samples will be drawn for each participant at baseline (before COVID-19 vaccination), and at 1, 3, 6, (and possibly 12) months post 2nd dose of COVID-19 vaccine. Humoral, B-cell and T-cell responses will be evaluated.

Condition Radiologically Isolated Syndrome, Multiple Sclerosis, Dermatite Atopique modérée ou grave, multiple sclerosis (ms)
Treatment COVID-19 Vaccination
Clinical Study IdentifierNCT05075499
SponsorSheba Medical Center
Last Modified on4 December 2022

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