Imaging for the Evaluation of Transthyretin Cardiac Amyloidosis Prevalence of Patients Over 65 Hospitalized in Cardiology Wards (the IMPACT Study)

  • STATUS
    Recruiting
  • End date
    Oct 6, 2023
  • participants needed
    400
  • sponsor
    Poitiers University Hospital
Updated on 20 October 2021

Summary

Heart failure with preserved ejection and hypertrophic cardiomyopathy are common diseases and often associated with transthyretin cardiac amyloidosis (TTR-CM), especially in elderly people. Nevertheless, research of TTR-CM is recommended in patients with ventricular hypertrophy without other cause such as valvular disease or hypertension. Therefore, the exact prevalence of TTR-CM remains unknown. We aim to determine the prevalence of TTR-CM in patients with ventricular hypertrophy and aged 60 years old, hospitalized in our cardiology department (CHU de Poitiers) by performing bone scintigraphy and research of AL amyloidosis.

Description

Not Provided

Details
Condition Transthyretin Cardiac Amyloidosis
Treatment Bony scintigraphy
Clinical Study IdentifierNCT05064839
SponsorPoitiers University Hospital
Last Modified on20 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient 60 years, hospitalised in cardiology wards of the Centre Hospitalier Universitaire of Poitiers
Left ventricle hypertrophy on echocardiography
Patient able to comply with study procedures
Patient legally free and not subject to any custody, guardianship, tutelage or subordination measures
Patient having signed an informed consent after clear and fair information on the study

Exclusion Criteria

CardiacTransplant
Complex congenital cardiopathies
Know diagnosis of amylosis
Contra-indication to bony scintigraphy : hypersensitivity to sodium oxidronate or one of its excipients, or to one of the components of radiopharmaceutic marked product
Subject not able to comply with study procedures
Patients not benefiting from a Social Security scheme or not benefiting from it through a third party
Persons benefiting from enhanced protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, patients staying in a health or social establishment, adults under legal protection, and patients in emergency situation
Women not menopausal
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