Long Term Brain Toxicity of Chemotherapy in Patients Treated for a Bone TumorDuring Childhood or Adolescence

  • STATUS
    Recruiting
  • End date
    Apr 7, 2025
  • participants needed
    530
  • sponsor
    Gustave Roussy, Cancer Campus, Grand Paris
Updated on 15 October 2021

Summary

To assess the neurocognitive outcomes in patients treated with chemotherapy for a malignant bone tumor during childhood and adolescence and the factors associated with neurocognitive impairment and/or complaints

Details
Condition Adults Treated During Childhood or Adolescence for a Malignant Bone Tumor (Osteosarcoma and Ewing Sarcoma)
Treatment MRI
Clinical Study IdentifierNCT05071001
SponsorGustave Roussy, Cancer Campus, Grand Paris
Last Modified on15 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

For study OSE A and B
Patients treated for a bone sarcoma: Ewing or osteosarcoma
Age under 19 years at initial diagnosis
Treated in the Pediatric Oncology Department of Gustave
For patients diagnosed between 01.01.2001 and 31.12.2010: patients alive in
complete remission at least 5 years after diagnosis
Treated with at least one course of HDMTX for osteosarcoma
Treated without HDMTX for Ewing sarcoma
Time interval between the end of treatment and inclusion >10 y
Age > 21 y at inclusion
Patients with informed consent signed
Patient under guardianship
Affiliated to French health insurance or beneficiary of the same or equivalent
For study OSE- B only
Treated with at least 8 courses of HDMTX for osteosarcoma
Treated without HDMTX for Ewing sarcoma
Patients with Ewing sarcoma will have to be matched with osteosarcoma patients according to age at the time of treatment, sex, and duration of follow-up
School level equivalent of at least the end of primary school

Exclusion Criteria

For study OSE A and B
Brain radiotherapy
Previous relapse except those treated by local treatment without any chemotherapy
Second malignancy treated with chemotherapy
High dose chemotherapy with stem cell support
Non-French speaking patients
Pregnant and breastfeeding women
For study OSE- B only
Patient deprived of his liberty by a judicial or administrative decision
Clear my responses

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