VIrtual Reality Glasses Use to Improve Lateropulsion and the Post-stroke Postural Vertical

  • STATUS
    Recruiting
  • days left to enroll
    83
  • participants needed
    40
  • sponsor
    University Hospital, Grenoble
Updated on 15 October 2021
stroke
Accepts healthy volunteers

Summary

VIRGIL is a monocentric interventional study aiming to investigate the effect of immersion in a virtual tilted room on modulation of the verticality representation (postural vertical [PV] and visual vertical [VV]), which in turn might affect body orientation (head and trunk). To this end, the investigators will conduct a within-person randomized trial including post-stroke patients and healthy participants.

Description

This project proposes to test the effect of immersion in a tilted virtual reality on verticality representation in hemisphere stroke patients showing lateropulsion and in healthy participants. The idea is to use the virtual reality as a tool to recalibrate the internal reference of verticality (contralesionally biased) in stroke patients and to experimentally create a bias in verticality perception of healthy participants, then to investigate how this modulation of the internal model of verticality might affect the erect posture. The investigators hypothesize that, in stroke patients, the recalibration of the verticality perception might ameliorate their lateropulsion, whereas in healthy participants, the experimental verticality bias introduced might induce a transient experimental lateropulsion. A transmodal modulation of the verticality perception, both on PV and VV, would imply a modulation by the virtual reality not only at the level of perception but also at the internal model of verticality, advocating for a powerful effect of this technology. The analysis of a post-effect (on verticality perception) that would continue after the intervention (immersion in the virtual titled room) would be a supplementary argument advocating for its clinical use in rehabilitation of post-stroke lateropulsion. To judge the effect of the immersion in tilted virtual reality, the following measures will be considered: (a) PV perception, (b) VV perception, (c) body orientation measured by inertial captors, and (d) weight-bearing asymmetry in erect posture assessed by posturography.

Details
Condition Cerebrovascular accident, Cognitive Deficits, brain disorders, Postural; Defect, Stroke, cognitive disorders, Cognitive Disorder, attention disorders, cerebrovascular accidents, strokes, cerebral, Brain Diseases, Cerebrovascular disease, Cognitive Deficit, brain disease, cognition disorders, brain disorder, Vascular Diseases, cerebrovascular diseases, disorder attention
Treatment Virtual Reality , immersion in a virtual titlted room
Clinical Study IdentifierNCT04911738
SponsorUniversity Hospital, Grenoble
Last Modified on15 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

stroke participants
Hospitalized in neurorehabilitation
Hemisphere stroke (Right or left)
Stroke delay < 6 months
Presence of lateropulsion assessed by the Scale for Contraversive Pushing (SCP) > 0.5
healthy participants
No history of stroke or others neurological pathologies
No balance disorders
No history of vestibular or dizzissness disorders

Exclusion Criteria

All
History of psychiatric disorders
Nyctophobia
Advanced heart failure
Severe trunk deformation with C7 lateral > 30 mm due to a independant cause beyond the stroke (i.e., scoliosis) or history of postural disorder
Stroke participants
Medical instability making the assessment impossible
Comprehension deficits with Boston Diagnostic Aphasia Examination gravity score 3
History of vestibular or dizzissness disorders
No previous neurological history interfering with balance
Inability to understand and execute simple orders
Severe untreated depression (Aphasic Depression Rating Scale (ADRS) score >15)
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