VIrtual Reality Glasses Use to Improve Lateropulsion and the Post-stroke Postural Vertical

  • days left to enroll
  • participants needed
  • sponsor
    University Hospital, Grenoble
Updated on 15 October 2021
Accepts healthy volunteers


VIRGIL is a monocentric interventional study aiming to investigate the effect of immersion in a virtual tilted room on modulation of the verticality representation (postural vertical [PV] and visual vertical [VV]), which in turn might affect body orientation (head and trunk). To this end, the investigators will conduct a within-person randomized trial including post-stroke patients and healthy participants.


This project proposes to test the effect of immersion in a tilted virtual reality on verticality representation in hemisphere stroke patients showing lateropulsion and in healthy participants. The idea is to use the virtual reality as a tool to recalibrate the internal reference of verticality (contralesionally biased) in stroke patients and to experimentally create a bias in verticality perception of healthy participants, then to investigate how this modulation of the internal model of verticality might affect the erect posture. The investigators hypothesize that, in stroke patients, the recalibration of the verticality perception might ameliorate their lateropulsion, whereas in healthy participants, the experimental verticality bias introduced might induce a transient experimental lateropulsion. A transmodal modulation of the verticality perception, both on PV and VV, would imply a modulation by the virtual reality not only at the level of perception but also at the internal model of verticality, advocating for a powerful effect of this technology. The analysis of a post-effect (on verticality perception) that would continue after the intervention (immersion in the virtual titled room) would be a supplementary argument advocating for its clinical use in rehabilitation of post-stroke lateropulsion. To judge the effect of the immersion in tilted virtual reality, the following measures will be considered: (a) PV perception, (b) VV perception, (c) body orientation measured by inertial captors, and (d) weight-bearing asymmetry in erect posture assessed by posturography.

Condition Cerebrovascular accident, Cognitive Deficits, brain disorders, Postural; Defect, Stroke, cognitive disorders, Cognitive Disorder, attention disorders, cerebrovascular accidents, strokes, cerebral, Brain Diseases, Cerebrovascular disease, Cognitive Deficit, brain disease, cognition disorders, brain disorder, Vascular Diseases, cerebrovascular diseases, disorder attention
Treatment Virtual Reality , immersion in a virtual titlted room
Clinical Study IdentifierNCT04911738
SponsorUniversity Hospital, Grenoble
Last Modified on15 October 2021


Yes No Not Sure

Inclusion Criteria

stroke participants
Hospitalized in neurorehabilitation
Hemisphere stroke (Right or left)
Stroke delay < 6 months
Presence of lateropulsion assessed by the Scale for Contraversive Pushing (SCP) > 0.5
healthy participants
No history of stroke or others neurological pathologies
No balance disorders
No history of vestibular or dizzissness disorders

Exclusion Criteria

History of psychiatric disorders
Advanced heart failure
Severe trunk deformation with C7 lateral > 30 mm due to a independant cause beyond the stroke (i.e., scoliosis) or history of postural disorder
Stroke participants
Medical instability making the assessment impossible
Comprehension deficits with Boston Diagnostic Aphasia Examination gravity score 3
History of vestibular or dizzissness disorders
No previous neurological history interfering with balance
Inability to understand and execute simple orders
Severe untreated depression (Aphasic Depression Rating Scale (ADRS) score >15)
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note