Analysis of Capillary Retinal and Papillary Vascularization in Patients With Amyotrophic Lateral Sclerosis - CAPISLA

  • STATUS
    Recruiting
  • End date
    Feb 14, 2023
  • participants needed
    94
  • sponsor
    University Hospital, Angers
Updated on 14 October 2021
neurological disorder
primary lateral sclerosis
riluzole
Accepts healthy volunteers

Summary

Amyotrophic Lateral Sclerosis, or Charcot's disease, is a neurodegenerative disease affecting motor neurons. The disease affects between 5 and 10 people per 100,000 in the world, nearly 7,000 patients are affected in France. The only therapeutic treatment available to date in France is riluzole, which slows the progression of the disease. Amyotrophic Lateral Sclerosis is the first degenerative disease affecting motor neurons. However, recent evidence suggests that the impairment extends beyond motor neurons alone.

Optical Coherence Tomography analyzes made it possible to highlight ophthalmologic damage in patients with Amyotrophic Lateral Sclerosis, in particular at the macula and papilla, although some results are contradictory.

No angiographic Optical Coherence Tomography analysis has been performed to date in patients with Amyotrophic Lateral Sclerosis. However, in the hypothesis of microvascular involvement participating in the pathophysiology of neurodegeneration in Amyotrophic Lateral Sclerosis, these examinations could provide relevant clinical and pathophysiological data by studying the retinal microvascularization of patients with the disease.

Details
Condition Spinal Cord Disorders, Myelopathy, Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS), lou gehrig's disease
Treatment angiographic optical coherence tomography
Clinical Study IdentifierNCT04686110
SponsorUniversity Hospital, Angers
Last Modified on14 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient Amyotrophic Lateral Sclerosis
Patient diagnosed with bulbar or spinal ALS defined according to El Escorial criteria (probable or certain)
Hospitalized in a day hospital at the Angers University Hospital as part of his usual follow-up
Control subject
Subject not affected by the disease studied and without a history of neurological disease
Subject matched in age and sex to a case (patient)
For all participants
Major upon inclusion
Signature of informed consent to participate in the protocol

Exclusion Criteria

Patient Amyotrophic Lateral Sclerosis and control subject
Simultaneous participation in another intervention protocol with an experimental treatment
Subject unable to express consent
Known ophthalmologic pathology (maculopathy, glaucoma, optic neuropathy, retinopathy whatever the etiology)
Diabetic subject
Cardiovascular history
Inability to perform the ophthalmological examinations of the study
Pregnant, lactating or parturient woman
Subject under duress psychiatric care
Subject to legal protection
Subject not affiliated or not beneficiary of a social security scheme
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