Esmolol for Myocardial Protection in Hypertrophic Obstructive Cardiomyopathy

  • End date
    Jul 1, 2023
  • participants needed
  • sponsor
    Meshalkin Research Institute of Pathology of Circulation
Updated on 19 October 2021


Perioperative blockage of beta-adrenoreceptors is widely used in cardiac and non-cardiac surgery to reduce the rate of cardiovascular complications. Several randomized-controlled studies and meta-analysis showed that esmolol reduces the incidence of myocardial ischemia and arrhythmias in cardiac surgery as well as enhances postoperative cardiac performance. No studies assessed the influence of esmolol in patients with hypertrophic obstructive cardiomyopathy undergoing cardiac surgery.

Condition Cardiomyopathy, hypertrophic obstructive cardiomyopathy, Hypertrophic Cardiomyopathy
Treatment Placebo, Esmolol
Clinical Study IdentifierNCT05073094
SponsorMeshalkin Research Institute of Pathology of Circulation
Last Modified on19 October 2021


Yes No Not Sure

Inclusion Criteria

Age > 18 years
Signed informed consent
Patient with hypertrophic obstructive cardiomyopathy undergoing surgery under cardiopulmonary bypass

Exclusion Criteria

History of adverse effects on esmolol
Urgent/emergent surgery
Administration of esmolol in 30 days before randomization
Participation in other randomized trial during same hospitalization
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