Muscle Evaluation of Patients Infected by the Coronavirus

  • STATUS
    Recruiting
  • End date
    Sep 16, 2022
  • participants needed
    138
  • sponsor
    Hospital Israelita Albert Einstein
Updated on 16 October 2021

Summary

Patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents risk to develop muscle weakness associated with prolonged period of mechanical ventilation support and hospital stay.

Description

Intensive care unit (ICU) acquired muscle weakness affects both respiratory and peripheral muscles and can contribute to worsen clinical and functional outcomes. In this way, ultrasonography muscle evaluation could help to identify early alterations guiding the therapeutic planning and allowing to monitor the interventions performed. Therefore, the investigators intend to follow up mechanically ventilated patients with confirmed diagnosis of COVID-19 during ICU stay to quantify the diaphragm, parasternal intercostal, abdominals and femoral quadriceps muscles thickness assessed by ultrasonography. Additionally, functional capacity, frailty and level of physical activity will be evaluated and followed for pre-admission condition and 30, 90 and 180 days after hospital discharge .

Details
Condition SARS-CoV-2 Acute Respiratory Disease, SARS-CoV-2 Acute Respiratory Disease, SARS-CoV-2 Acute Respiratory Disease
Treatment Muscle ultrasound evaluation
Clinical Study IdentifierNCT05063214
SponsorHospital Israelita Albert Einstein
Last Modified on16 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

patients admitted to ICU
having a confirmed diagnosis of COVID-19
requiring invasive mechanical ventilation

Exclusion Criteria

exclusive palliative care
neuromuscular diseases
patients who evolve with the need for lower limb amputation
previous known diaphragm malformations and dysfunctions
patients transferred from other institutions under invasive mechanical ventilation
clinical conditions that make the respiratory and peripheral muscle assessment through ultrasound unfeasible
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