Denosumab and Screw Fixation for Osteoporotic Compression Fracture

  • day left to enroll
  • participants needed
  • sponsor
    Shenzhen People's Hospital
Updated on 9 October 2021
Accepts healthy volunteers


Evaluation of bone mineral density and function at 1 year after screw internal fixation of osteoporotic vertebral compression fractures with desuzumab: a parallel double-blind randomized controlled clinical trial


Conduct a single-center, double-blind, randomized controlled clinical trial according to clinical Trial Reporting Standards (CONSORT). Bone mineral density and function were compared 1 year after screw internal fixation of osteoporotic vertebral compression fracture (OVCF) with desomumab versus placebo in Shenzhen People's Hospital from September, 2021 to September, 2022. The study was approved by Shenzhen People's Hospital and informed consent was signed

Condition Denosumab and Screw Internal Fixation of Osteoporotic Vertebral Compression Fracture
Treatment Denosumab
Clinical Study IdentifierNCT05065164
SponsorShenzhen People's Hospital
Last Modified on9 October 2021


Yes No Not Sure

Inclusion Criteria

Must be age between 40 and 90 years old
X-ray diagnosis of 1-2 vertebral compression fractures
DEXA test BMD T value was less than -1
fracture history lasted within 6 weeks
MRI showed bone marrow edema of injured segment
lower back pain, local spines tenderness

Exclusion Criteria

Must be able to have no posterior vertebral wall fracture
Must be able to have no patients with intervertebral fissure
Must be able to have no infection
Must be able to have no malignancy
Must be able to have no neurological dysfunction
Must be able to have no previous use of anti-osteoporosis drugs within 6 weeks
Must be able to have no inability to perform magnetic resonance imaging
Must be able to have no prior back surgery
Must be able to have no other established contraindications for elective surgery
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note