ICCRT vs. CRT for Locally Advanced Nasopharyngeal Carcinoma

  • End date
    Aug 31, 2027
  • participants needed
  • sponsor
    First Affiliated Hospital, Sun Yat-Sen University
Updated on 7 October 2021


This trial is a multi-center phase III clinical trial. The purpose of this trial is to explore whether concurrent chemoradiotherapy is not inferior to induction chemotherapy combined with concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma.

Condition Locally Advanced Nasopharyngeal Carcinoma
Treatment Concurrent chemotherapy, induction chemotherapy, Definitive Radiotherapy
Clinical Study IdentifierNCT05062005
SponsorFirst Affiliated Hospital, Sun Yat-Sen University
Last Modified on7 October 2021


Yes No Not Sure

Inclusion Criteria

Age 18-65 years old
Pathologically confirmed non-keratinizing nasopharyngeal carcinoma
Stage T3-4N0-1 (according to the UICC/AJCC 8th)
No distant metastasis
Have not received anti-cancer treatment in the past
ECOG (Eastern Cooperative Oncology Group of the United States): 0-1
Adequate hematologic, hepatic and renal function

Exclusion Criteria

The purpose of treatment is palliative
Diagnosed with other malignant tumors at the same time
Malignant tumor history
Pregnancy or breastfeeding, or expect to become pregnant during the clinical trial period
Combined serious illness
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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