Nasal High-flow Compared to Non-invasive Ventilation in Treatment of Acute Acidotic Hypercapnic Exacerbation of Chronic Obstructive Pulmonary Disease
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- STATUS
- Recruiting
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- End date
- Oct 6, 2024
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- participants needed
- 720
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- sponsor
- University of Leipzig
Summary
The ELVIS study compares the nasal high-flow to non-invasive ventilation in treatment of acute acidotic hypercapnic exacerbation of chronic obstructive pulmonary disease.
Description
The ELVIS study is a prospective, randomized, multi-centre open label trial following a non-inferiority design to compare the nasal high-flow (NHF) to non-invasive ventilation (NIV) in treatment of acute acidotic hypercapnic exacerbation of chronic obstructive pulmonary disease. Accoring to the randomization the patient is treated with NHF or NIV until discharge. A change of device is possible, if switch criteria are fulfiled OR need for intubation criteria are met before 72h (timepoint for primary endpoint).
Details
| Condition | COPD Exacerbation Acute |
|---|---|
| Treatment | Respiratory support with nasal high-flow (NHF), Respiratory support with non-invasive ventilation (NIV) |
| Clinical Study Identifier | NCT04881409 |
| Sponsor | University of Leipzig |
| Last Modified on | 26 March 2022 |
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