A FIH Study of YH35324 in Atopic Healthy Subjects or Subjects With Mild Allergic Diseases
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- STATUS
- Recruiting
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- End date
- Dec 20, 2022
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- participants needed
- 68
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- sponsor
- Yuhan Corporation
Summary
The purpose of this study is to evaluate the safety, tolerability, PK, and PD following subcutaneous injections of YH35324 in atopic healthy subjects or adult subjects with mild allergic diseases. Eligible subjects will be randomized to the YH35324 group, the placebo group, or the omalizumab group.
Description
YH35324 is a drug under development as a novel therapeutic agent for various IgE-mediated allergic diseases. Since YH35324 has a high binding affinity to human IgE, it prevents serum IgE from binding to receptors on mast cells and basophil, thereby inhibiting histamine release caused by degranulation when exposed to allergens Based on its non-clinical study results, this study aims to evaluate the safety, tolerability, PK, and PD following subcutaneous injections of YH35324 in atopic healthy subjects or subjects with mild allergic diseases.
Details
| Condition | Atopic Healthy Subjects, Adult Subjects With Mild Allergic Diseases |
|---|---|
| Treatment | Placebo, omalizumab, YH35324 |
| Clinical Study Identifier | NCT05061524 |
| Sponsor | Yuhan Corporation |
| Last Modified on | 22 March 2022 |
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