Opioid Antagonism in Hypogonadotropic Hypogonadism

  • End date
    Feb 28, 2025
  • participants needed
  • sponsor
    Stephanie B. Seminara, MD
Updated on 7 July 2022
klinefelter syndrome
secondary hypogonadism
idiopathic hypogonadotropic hypogonadism


The goal of this study is to evaluate the effects of opioid antagonists on the hypothalamic-pituitary-gonadal axis in subjects with idiopathic hypogonadotropic hypogonadism (HH).


Assignment: Each study subject will serve as their own control.

Delivery of Interventions:

  • Prior to the study visit, subjects will undergo a review of their medical history and screening laboratories.
  • On the days of the inpatient study, the subjects will
  • Day 1: Undergo q10 min blood sampling for 13 hours
  • Receive 3 kisspeptin intravenous (IV) boluses
  • Receive 1 Gonadotropin Releasing Hormone (GnRH) IV bolus
  • Day 2: Undergo q10 min blood sampling for 13 hours
  • Receive a naloxone bolus followed by a naloxone infusion
  • Receive 3 kisspeptin IV boluses
  • Receive 1 GnRH IV bolus

Condition Hypogonadotropic Hypogonadism
Treatment GnRH, naloxone, kisspeptin, GnRH, naloxone
Clinical Study IdentifierNCT04975334
SponsorStephanie B. Seminara, MD
Last Modified on7 July 2022


How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note