PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation

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    University Health Network, Toronto
Updated on 8 October 2021


Radiotherapy (RT) is a well-known and established therapy or adjuvant therapy for the treatment of thoracic cancer It uses a high energy radiation from x-rays, gamma rays and other charged particles that assist in damaging the cancer DNA.

PET/MR as imaging biomarkers for cardiopulmonary dysfunction with a focus on Pulmonary hypertension (PH).

Despite the measures taken to reduce the total radiation dose and to limit the radiation to normal tissues, there is evidence of transient or permanent radiotherapy induced myocardial and pulmonary dysfunction leading to PH in patients who receive radiotherapy above a certain threshold of received dose.

To be able to Demonstrate correlation of combined PET/MR and plasma metabolomics markers in patients at risk of developing cardiopulmonary disfunction after RT.


RT is a well-known and established therapy or adjuvant therapy for the treatment of thoracic malignancies (breast cancer, lung cancer, lymphoma and others). It usually uses high energy radiation from x-rays, gamma rays or other charged particles to induce DNA damage in malignant cells. Despite the measures taken to reduce the total radiation dose and to limit the radiation to normal tissues, the signs and symptoms of radiation induced cardiopulmonary dysfunction (RICPD) still persist. However, in the majority of cases, it remains unclear which cardiopulmonary damage is the main /leading cause for the clinical symptoms the patients are experiencing.

Hybrid PET/MRI is a promising technique that allows for truly simultaneous molecular, anatomic and functional imaging of the cardiopulmonary system. The simultaneity is an important aspect in this proposed study since only parameters measured at the same time in PET and MR can be used for an integrated, multimodality parameter for possible detection and prognostication of the different underlying processes of cardiopulmonary dysfunction after RT. Furthermore, certain PET-uptake of the RV have to be corrected for RV mass which is only possible with concomitant anatomical imaging. MR imaging and PET at different time point are not accurately reflective of the underlying pathophysiological pathways and metabolic state at the specific time points pre- and post radiotherapy. To our knowledge, there are no online publications of its use in the diagnosis and prognostication of cardiopulmonary dysfunction after RT and specifically PH.

Condition Complicated Grief, Chronic Renal Anemia, Renal Anemia, Joint Injuries, Catheter Complications, Spinocerebellar Disorders, Surviving Abuse, Primary Insulin Hypersecretion, Cancer Treatment, Indikation: Diabetes - Typ II, Myopic Macular Degeneration, Late Infantile Neuronal Ceroid Lipfuscinsosis, Effects of Chemotherapy, Dental Filling, Functional Dyspepsia, Anemic Cancer, Partial Medial Meniscectomy, Severe Premenstrual Symptom, Abdominal Surgery, Gambling Problems, Pulmonary Hypertension, Cancer Prevention, Pseudobulbar Affect, Nerve Injury, Testotoxikose, Recurrent Pregnancy Loss, Infantile Fibrosarcoma, Memory Problems, Stasis Dermatitis, Serial Evaluation of Ductal Epithelium, Open Heart Surgery, Chronic Pelvic Pain, Low Testosterone, Pulmonary Arterial Hypertension, Habit Reversal, Pelvic Adhesions, Mental Disability, Spine Athroplasty
Treatment PET/MR with 18F-FDG
Clinical Study IdentifierNCT04901884
SponsorUniversity Health Network, Toronto
Last Modified on8 October 2021


Yes No Not Sure

Inclusion Criteria

Age 18 years
Biopsy or otherwise clinically proven thoracic malignant mass which is intended to be treated with radio(chemo)therapy
Intention to treat with radio(chemo)therapy with incidental cardiac irradiation of at least 25Gy
A negative urine or serum pregnancy test within the two week interval immediately prior to imaging, in women of child-bearing age
Ability to provide written informed consent to participate in the study (for all components of the trial: imaging with cardiac PET/MR, blood sampling for plasma metabolomics and circulating DNA)

Exclusion Criteria

Contraindication for MR as per current institutional guidelines
Contraindication for Gadolinium injection as per current institutional guidelines
Inability to lie supine for at least 45 minutes
Any patient who is pregnant or breastfeeding
Any patient with known hypersensitivity to 18F-FDG
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