Sleep Duration and Blood Pressure During Sleep

  • STATUS
    Recruiting
  • End date
    Feb 28, 2024
  • participants needed
    66
  • sponsor
    Columbia University
Updated on 14 October 2021
Accepts healthy volunteers

Summary

The purpose of this study is to examine the impact that sleep duration has on blood pressure (BP) levels during sleep. The investigator will examine the effect of an 8-week sleep hygiene/extension intervention vs. control on sleep BP.

Description

Short sleep duration (SSD), defined as sleeping less than 7 hours per night, affects over 33% of US adults and is associated with increased mortality. SSD is a modifiable risk factor for obesity, type 2 diabetes, and HTN. Cross-sectional studies have demonstrated that SSD is associated with higher sleep BP levels. SSD is also associated with non-dipping BP which is primarily explained by higher sleep BP levels. However, many of the cross-sectional studies have included adolescent participants or have not used reference standard measures of sleep duration such as wrist actigraphy. Manipulating sleep duration experimentally through sleep restriction or deprivation is associated with higher 24-hour and sleep BP levels. In contrast, there is scarce data on the effect of sleep extension on sleep BP levels among adults with SSD.

Eligible community individuals with short sleep duration will be randomized to sleep extension vs. control using 24-hour ambulatory blood pressure monitoring (ABPM) and actigraphy in the naturalistic environment. Individuals will be assessed throughout the study using questionnaires, activity monitoring via a Fitbit device (for 8 weeks), blood pressure monitoring using a 24-hour ABPM device, and heart rate variability monitoring for 24-hours.

Details
Condition Elevated Blood Pressure, Blood pressure, Sleep Disorders (Pediatric), Hypertension, high blood pressure, arterial hypertension, Blood Pressure, Vascular Diseases, raised blood pressure, increase blood pressure, High Blood Pressure (Hypertension), Diabetes and Hypertension, High Blood Pressure (Hypertension - Pediatric), Sleep Disorders, Sleep
Treatment Sleep hygiene/extension intervention, Control care
Clinical Study IdentifierNCT05062161
SponsorColumbia University
Last Modified on14 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

English speaking adults
Age 18 and older
Sleep duration < 7 hours per night as assessed via daily self-report of sleep hours

Exclusion Criteria

Inability to read or write in English
Pregnant or plans to get pregnant within study period
Arm circumference >50 cm
Lymphedema of the arm or unable to wear ABPM device for 24 hours or wrist actigraphy for 8 weeks
End-stage renal disease (ESRD) on dialysis
Unreliable internet or phone/text access
High risk of Obstructive Sleep Apnea (OSA) (using the Berlin Questionnaire or diagnosis of OSA or use continuous positive airway pressure device)
High risk of insomnia (using the Insomnia Severity Index), or a known prior history of insomnia, and/or use of prescription sleep aides
High risk of depression (using the Patient Health Questionnaire Depression Scale: PHQ-8)
Perimenopausal women who have hot flashes (using the Menopause Rating Scale (MRS) questionnaire, administered only to females age 45-65)
Plan to travel out of state and/or internationally during the study period
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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