OFA in Thoracic Surgery

  • End date
    Dec 1, 2025
  • participants needed
  • sponsor
    Shanghai Zhongshan Hospital
Updated on 15 May 2022


to investigate the efficacy and safety of opioid-free anesthesia for non-small-cell lung cancer resection and its underlying clinical value


Opioids used to have its irreplaceable role in standard opioid-based anesthesia, yet with the help of hypnotics, local anesthetics, anti-inflammatory drugs, α-2 agonists and epidural techniques, opioid-free anesthesia (OFA) has been proved to be safe and feasible for non-cardiac major surgeries. Opioid-sparing anesthesia (OSA) is encouraged by the needs of enhanced recovery and recommended by the latest guidelines for anesthesia of lung surgery. According to previous studies, both opioid-sparing and opioid-free anesthesia would reduce the incidence of opioid-related adverse events and speed up the postoperative recovery to some extent, yet no studies ever are dedicated to compare these two different techniques.

Condition Thoracic Cancer
Treatment opioid free anesthesia, Opioid-sparing anesthesia
Clinical Study IdentifierNCT05063396
SponsorShanghai Zhongshan Hospital
Last Modified on15 May 2022


Yes No Not Sure

Inclusion Criteria

going through thoracoscopic lung surgery including lobectomy, segmentectomy, single or multiple wedge resection, and two of the above procedures combined
able to complete the pain scoring face-to-face
no cognitive dysfunction or history of anesthetic drug allergy
ASA grade I-II

Exclusion Criteria

psychological disorders
Clear my responses

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