Napping, Sleep, Cognitive Decline and Risk of Alzheimer's Disease

  • STATUS
    Recruiting
  • End date
    Jul 25, 2023
  • participants needed
    40
  • sponsor
    University of California, San Francisco
Updated on 25 October 2022
cognitive impairment
alzheimer's disease
cognitive decline
mild cognitive impairment
neurological disorder

Summary

This study aimed to pilot test a non-pharmacological (behavioral) treatment program targeting improved cognition through improving 24-h sleep-wake cycle in people with mild cognitive impairment (MCI) or mild Alzheimer's disease. A treatment program incorporating bright light therapy and a modified cognitive behavioral therapy for insomnia will be developed to address 24-hour patterns of sleep. We will then pilot test its feasibility and explore its preliminary effects on improving sleep/napping and cognition in patients with MCI or mild Alzheimer's disease.

Details
Condition Sleep, Alzheimer Disease, Cognitive Impairment, Aging, CBT
Treatment placebo intervention, Sleep intervention
Clinical Study IdentifierNCT03256539
SponsorUniversity of California, San Francisco
Last Modified on25 October 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

≥65 years old
Memory complaints verified by an informant
Clinical diagnosis of mild cognitive impairment (MCI) or mild Alzheimer's Disease
General cognitive performance sufficiently persevered such that a diagnosis of Alzheimer's disease cannot be made by the site physician
No evidence (CT or MRI scans within 12 months prior to screening) of infection, infarction, or other focal lesions and no clinical symptoms suggestive of intervening neurological disease
Adequate visual and auditory acuity to allow neuropsychological testing
Meets ICSD-2 criteria for insomnia or circadian rhythm disorders, or shows actigraphy evidence of sleep disturbances and excessive napping

Exclusion Criteria

Any major neurologic disease other than suspected incipient Alzheimer's disease, such as Parkinson's disease, multi-infarct dementia, multiple sclerosis, seizure disorder, Huntington's disease, brain tumor or history of significant head trauma
Any comorbid psychiatric conditions or severe personality disorder within the past 2 years (by DSM-IV), such as major depression, bipolar disorder, schizophrenia and other psychotic features
Any uncontrolled medical conditions or systemic illness that might lead to difficulty complying with the study protocol
History of alcohol or substance abuse within the past 2 years
Any inadequately treated primary or secondary sleep disorder (due to medical conditions) that might confound the association
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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