Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer

  • End date
    Mar 31, 2023
  • participants needed
  • sponsor
    Samsung Medical Center
Updated on 4 October 2021
Accepts healthy volunteers


The purpose of the study is to investigate the effects of metformin in addition to the conventional progestin therapy in the fertility-sparing treatment of early stage endometrial cancer.

Condition Endometrial Cancer Stage I
Treatment Metformin
Clinical Study IdentifierNCT04792749
SponsorSamsung Medical Center
Last Modified on4 October 2021


Yes No Not Sure

Inclusion Criteria

Endometrial cancer radiologic International Federation of Obstetrics and Gynecology (FIGO) stage IA patients
Endometrioid endometrial cancer patients
FIGO cellular differentiation grade 1 patients
Patients who wish to preserve fertility
Patients who understand that the recommended treatment of endometrial cancer is surgical treatment even in early stages, but still wish to preserve fertility and avoid surgical treatment
Patients who have good performance status (Eastern Cooperation Oncology Group (ECOG) performance score equal to or greater than 3)
Patients who are not contraindicated to the progestin therapy
Patients who are not contraindicated to the use of metformin

Exclusion Criteria

Patients who have already received chemotherapeutic or radiotherapeutic treatments for endometrial cancer
Patients whose disease is already advanced and not indicated for fertility-sparing treatment
Patients whose tumor cellular differentiation grade is greater than FIGO grade 1
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note