Validation of a Predictive Rule for the Diagnosis of Viral Meningitis in Adult Emergency Departments (Adult-BMS)

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    Centre Hospitalier le Mans
Updated on 24 March 2022
bacterial meningitis


Meningitis is the development of an inflammatory reaction in the meningeal space, most often of infectious origin. Many pathogens can cause meningitis, the severity of which varies greatly. Patients presenting with a febrile meningeal syndrome are most often managed in the emergency room, where the challenge for physicians is to quickly differentiate bacterial and viral meningitis.

Viral meningitis is the most common, with enterovirus meningitis having a classically excellent prognosis. Bacterial meningitis is less frequent but more serious.The current public health objective is to save antibiotics.

Investigator hypothesizes that the BMS score can be used to exclude bacterial meningitis in the emergency department in an adult European population of patients with suspected bacterial meningitis.

Condition Meningitis
Clinical Study IdentifierNCT05062642
SponsorCentre Hospitalier le Mans
Last Modified on24 March 2022


Yes No Not Sure

Inclusion Criteria

Patient admitted to the Adult Emergency Department of CH Le Mans,CHU Angers, CHU Nantes or Beaujon Hospital
Over 18 years old
Having had a lumbar puncture during their stay in the Adult Emergency Department
Having had a diagnosis of meningitis defined as a pleocytosis ≥ 5leukocytes/mm3 after correction with CSF red blood cells at a standardized ratio of 500/1

Exclusion Criteria

Antibiotic therapy within 72 hours of inclusion
Immunosuppression from any cause
Presence of petechiae or purpura
History of recent neurosurgery or head trauma
Other associated bacterial infection
Inability to collect information for the BMS score calculation or primary endpoint (e.g., transfer to another facility)
Minor or adult patient under guardianship or protection
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