Low GI Diet Effects on Non-Alcoholic Fatty Liver Disease

  • End date
    Oct 9, 2023
  • participants needed
  • sponsor
    University of Nottingham
Updated on 9 October 2021


A 2 x 2 cross-over dietary intervention trial designed to investigate the effects of low glycemic index (LGI) versus high glycemic index (HGI) diet on hepatic fat accumulation and gut microbiota composition in participants with NAFLD.

Participants will be allocated randomly to a 2-week either high GI (HGI) or low GI (LGI) diet followed by a 4-week wash-out period and then the LGI or HGI diet, opposite to the first 2-weeks (N= 16).

Condition steatohepatitis, LIVER DISEASE, Nutritional and Metabolic Disease, Liver Disease, Liver Disorders, Fatty Liver, hepatic steatosis
Treatment Low Glycemic Index Diet, High glycemic index diet
Clinical Study IdentifierNCT04415632
SponsorUniversity of Nottingham
Last Modified on9 October 2021


Yes No Not Sure

Inclusion Criteria

Adult males and females aged from 18 to 65 years (balanced number)
Detected NAFLD by CAP-FibroScan >288dB/m or by MRI-PDFF) > 5% fat of liver weight
Body mass index 25 kg/m2
Have current moderate to high GI diet intake of 60 (Assessed from a completed 7-day food diary)
Abdominal obesity (Waist circumference > 102 cm for males and > 88 cm for females)
Able to give informed consent
Able to undergo MRI/S and CAP-FibroScan

Exclusion Criteria

Current smokers and excessive alcohol drinkers (> 14 units/week)
Perimenopausal (irregular periods) women
Participants with other liver abnormalities
Participants with history of gastrointestinal surgeries, depression, eating disorders or difficulties
Participants using pharmacologic agents for obesity or NAFLD
Participants with type 1 diabetes
Participants with type 2 diabetes on second line medications (eg GLP-1 analogues, sulfonylureas)
Participation in any other trial in the last 3 months
Participants on any special diets (e.g. vegetarians)
Intolerance to foods included in the diet plan
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