A Multicenter, Open-label, Phase 2 Basket Study of MK-7684A, a Co-formation of Vibostolimab (MK-7684) With Pembrolizumab (MK-3475), With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors
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- STATUS
- Recruiting
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- End date
- Feb 19, 2025
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- participants needed
- 610
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- sponsor
- Merck Sharp & Dohme LLC
Summary
The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of pembrolizumab/vibostolimab co-formulation (MK-7684A) with or without other anticancer therapies in participants with selected advanced solid tumors. The primary hypothesis is that pembrolizumab/vibostolimab co-formulation is superior to pembrolizumab alone in terms of objective response rate or progression-free survival in participants with cervical cancer.
Details
| Condition | Uterine Cervical Neoplasms, Endometrial Neoplasms, Squamous Cell Carcinoma of Head and Neck, Gallbladder Neoplasms, Cholangiocarcinoma, Esophageal Neoplasms, Triple Negative Breast Neoplasms, Hepatocellular Carcinoma, Urinary Bladder Neoplasms, Ovarian Neoplasms, Stomach Neoplasms |
|---|---|
| Treatment | Capecitabine, cisplatin, docetaxel, carboplatin, Gemcitabine, Paclitaxel, bevacizumab, Pembrolizumab, Oxaliplatin, 5-fluorouracil, Lenvatinib, Pembrolizumab/Vibostolimab Co-Formulation |
| Clinical Study Identifier | NCT05007106 |
| Sponsor | Merck Sharp & Dohme LLC |
| Last Modified on | 24 October 2022 |
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