Brain Stimulation, Clinical Symptoms and Cognition

  • End date
    Aug 31, 2024
  • participants needed
  • sponsor
    University of California, Davis
Updated on 15 December 2021
transcranial direct current stimulation
schizoaffective disorder
auditory hallucinations
Accepts healthy volunteers


The purpose of this study is to test the impact of non-invasive brain stimulation, transcranial direct current stimulation (tDCS), on auditory hallucinations, negative symptoms and cognition in schizophrenia. Clinical measures will be used to assess clinical symptoms and cognitive performance to test the hypothesis that a course of tDCS can reduce auditory hallucinations and negative symptoms in schizophrenia.

Condition Schizophrenia
Treatment Transcranial Direct Current Stimulation
Clinical Study IdentifierNCT05053451
SponsorUniversity of California, Davis
Last Modified on15 December 2021


Yes No Not Sure

Inclusion Criteria

Participants must be able to sufficiently speak and understand English so as to be able to understand and complete cognitive tasks
All subjects must have the ability to give valid informed consent
No children under the age of 18 will be recruited
Diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
Stable outpatient or partial hospital status
Normal IQ (>70; IQ will be measured by administering the Wechsler Abbreviated Scale of Intelligence (WASI) test)

Exclusion Criteria

Implanted electrical (brain and spinal) stimulators
Implanted defibrillator
Metallic implants
Skin damage or skin conditions such as eczema at the sites where electrodes will be placed
Hair styles hindering the placement of electrodes
Cranial pathologies
Head trauma
Mental retardation
Any known history of neurological disorders (including epilepsy, amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), stroke, cerebral palsy, any DSM-5 axis I psychiatric disorder (for healthy control subjects), autism)
Uncorrected vision problems that would hinder cognitive testing (this also pertains to subjects with color blindness in tasks where discriminating colored objects/items is necessary for successful performance)
Substance dependence in the past six months
Substance abuse in the past month
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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