Pencil Beam Proton Therapy for Recurrences in Anal Cancer Patients Previously Treated With Radiotherapy (DACG 5)

  • End date
    Jul 6, 2030
  • participants needed
  • sponsor
    University of Aarhus
Updated on 1 October 2021


This protocol aims to determine toxicity and efficacy of re-irradiation for patients with recurrences from anal cancers with dose-escalated pencil beam proton therapy either pre-operative for marginally resectable recurrences or as a definitive treatment strategy (un-resectable, operation declined etc.). The over-all aim is to improve local tumor control with acceptable side effects.

Condition Recurrent Anal Cancer, Anal Cancer, Rectal Cancer, anal carcinoma
Treatment Pencil beam proton therapy
Clinical Study IdentifierNCT05055635
SponsorUniversity of Aarhus
Last Modified on1 October 2021


Yes No Not Sure

Inclusion Criteria

Recurrent anal cancer
Bioptically verified (squamous cell carcinoma)
Available dose plan from primary radiotherapy
Previous RT (>30Gy EQD2)
Evaluated in MDT-conferences (Herlev, Aarhus)
Age>18 years
PS 0-2
Adequate organ function
Written informed consent

Exclusion Criteria

Distant metastases deemed without curative intended treatment options (PET-CT)
Unable to undergo MRI, PET-CT
Inability to attend full course radiotherapy and follow up in the outpatient clinic
Clear my responses

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