A Crossover Study Evaluating 3 Non-medicated Silicone Intravaginal Rings

  • sponsor
    The Population Council, Inc.
Updated on 5 April 2022
Accepts healthy volunteers


This is a study evaluating 3 non-medicated silicone vaginal rings. The primary aim of this study is to find out which ring size women like best and if male partners prefer one ring size over another. We want to know if the size of the ring makes a difference in how easy or difficult it is for women to use the ring correctly.


Each couple will use each of the 3 non-medicated silicone vaginal rings in 3 different sizes for 30 days per vaginal ring. After enrollment, women will attend 3 additional in-clinic visits and men will attend 3 additional remote (virtual) visits. Women and men will respond to questionnaires before and after each ring, and at the end of the study.

  • 5 study visits over 6 months
  • Questionnaires and an interview
  • Physical exam and STI screening tests
Compensation: Female participants can receive up to $515 and males can receive up to $275 for participation.

Condition monogomy, heterosexual, Healthy Volunteers, preventative health
Clinical Study IdentifierTX283492
SponsorThe Population Council, Inc.
Last Modified on5 April 2022


Yes No Not Sure

Inclusion Criteria

18 years of age and older
HIV negative
Have one sexual partner of the opposite sex
Both male and female partners willing and eligible to participate in the study
Willing to use an effective non-vaginal method of birth control

Exclusion Criteria

Less than 18 years of age
HIV positive
Partner not willing to participate
Not using effective non-vaginal method of birth control
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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