Understanding the Impact of Melatonin Use on Adolescent Functioning: A Pilot and Feasibility Trial of the Melatonin Adolescent Research Study (MARS) (MARS)

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  • sponsor
    Loma Linda University
Updated on 16 October 2022


The present study will use a within-person, randomized cross-over experimental design to test the effects of exogenous melatonin supplementation on the sleep and daytime functioning of typically developing adolescents with short or disrupted sleep of behavioral origins (i.e., difficulty falling asleep, staying asleep, or premature waking resulting in short or disrupted sleep not attributed to an organic sleep condition).

Condition Sleep Disorders in Children
Treatment Placebo, Melatonin
Clinical Study IdentifierNCT04588233
SponsorLoma Linda University
Last Modified on16 October 2022


Yes No Not Sure

Inclusion Criteria

Self-identified sleep difficulties (e.g., difficulty falling asleep, staying asleep, or premature waking resulting in short or disrupted sleep)
Ages 13 to 17 years old
Able to understand, read, and write in English
Melatonin naive

Exclusion Criteria

Use of psychiatric medication
Drug(s), or supplements known to affect sleep
History of head injury or concussion with loss of consciousness >1 minute
Daily consumption of >1 caffeinated beverage
Risk for any organic sleep disorder (e.g., obstructive sleep apnea, restless leg syndrome)
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