Erenumab For Treatment of Hemicrania Continua

  • days left to enroll
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 29 September 2021


This research is being conducting to learn if the study drug erenumab is successful in treating hemicrania continua. The study is also evaluating the safety and tolerability of erenumab in individuals being treated for hemicrania continua.

Condition Hemicrania Continua
Treatment Erenumab
Clinical Study IdentifierNCT04303845
SponsorMayo Clinic
Last Modified on29 September 2021


Yes No Not Sure

Inclusion Criteria

Adults over the age of 18-66
At least a 12 month history of hemicrania continua (unremitting subtype) according to International Classification of Headache Disorders, 3rd Edition (ICHD-3)1
Previous or current complete response to indomethacin
Stable preventive treatment for at least 2 months and no anticipated need to adjust/add current headache prevention treatment

Exclusion Criteria

Nonresponse to a therapeutic dose of indomethacin for hemicrania continua when used for at least 1 week
Pregnant or lactating subjects
Use of barbiturate or opioid >6 days per month; history of chronic migraine
History of previous trigeminal-autonomic cephalalgia
History within previous 2 months of interventional procedure for headache (occipital or other extracranial nerve block, sphenopalatine ganglion block, cervical facet block, facet rhizotomy)
History of cranial nerve/rhizolysis
Botulinumtoxin injection with previous 4 months
Parenteral infusion of or oral corticosteroid use for more than 3 days within 4 weeks prior to screening phase
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What happens next?
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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