Increase Vaccine Uptake in Adolescent in Rural South (INVEST)

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Duke University
Updated on 25 March 2022
Accepts healthy volunteers


The benefits of adolescent vaccines are well known for preventing meningococcal infection and human papillomavirus (HPV)-related pre-cancerous lesions. Yet, many adolescents in the United States (US) remain under-vaccinated, with vaccination rates among rural adolescents significantly lower than among their urban peers. In addition, there are urban-rural disparities in the coverage of HPV vaccine, particularly in Southern states like North and South Carolina, which currently fall below the Healthy People 2020 goal of ≥80% coverage. The goal of the proposed study is to evaluate the feasibility and preliminary efficacy of a school-based intervention for increasing vaccine uptake among adolescents in rural North and South Carolina.

Condition Vaccine Hesitancy
Treatment INVEST
Clinical Study IdentifierNCT04999267
SponsorDuke University
Last Modified on25 March 2022


Yes No Not Sure

Inclusion Criteria

Students in the 6th, 7th or 8th grade attending public middle schools in Cherokee County, South Carolina or Rockingham County, North Carolina school districts
Adolescents in control counties in North and South Carolina

Exclusion Criteria

Individuals not able to consent for themselves
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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