HE4 in the Diagnostic Approach of Endometrial Cancer in Patients With Postmenopausal Bleeding

  • STATUS
    Recruiting
  • participants needed
    100
  • sponsor
    Nantes University Hospital
Updated on 5 October 2022
cancer
hysterectomy
ca-125

Summary

This study aims to explore the sensitivity of an innovative marker, HE4, in the diagnosis approach of endometrial cancer in case of postmenopausal bleedings.

Description

Endometrial cancer is the most common pelvic gynecological cancer in France, ranking 5th among cancers in women in terms of incidence.

The most frequent symptom is post-menopausal bleeding and is one of the primary reasons for consultation in gynecological emergencies.

The diagnosis of endometrial cancer is made by histological analysis of endometrial tissue taken during a surgical intervention. The latter is mostly reassuring.

These interventions are often performed in mild situations and there is currently no element to be sufficiently reassuring to avoid surgery.

At present, there is no biological marker used in current practice. In the population of patients with post-menopausal bleeding requiring surgical exploration for diagnosis, the pathology results are often reassuring. These procedures could have been avoided, especially as these patients often have numerous co-morbidities and these surgeries are therefore more risky. The appearance of a new tumour marker could be useful in the management of these patients and avoid many unnecessary and risky surgeries

This study aims to explore the sensitivity of an innovative marker, HE4, in the diagnosis approach of endometrial cancer in case of postmenopausal bleedings.

Details
Condition Menopause, ca 125, Disorder of uterus NOS, Postmenopause, Endometrial Cancer, Cancer Biomarker, Vaginal Bleeding, Uterine Cancer, Endometrial Carcinoma, ca-125, cancer antigen 125, CA-125 Antigen, uterine bleeding, Uterine Disorders, Post Menopause, Hemorrhage
Treatment Patients with Post menopausal bleeding, CA125 and HE4 assays
Clinical Study IdentifierNCT04867109
SponsorNantes University Hospital
Last Modified on5 October 2022

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