High-flow Nasal Cannula Oxygenation Decrease Hypoxia in Sedated Gastrointestinal Endoscopes in Obesity

  • days left to enroll
  • participants needed
  • sponsor
    RenJi Hospital
Updated on 27 September 2021


Hypoxia is the most common adverse event during gastrointestinal endoscopes sedated with propofol and sufentanil, especially in obese people. In the present study, high-flow nasal cannula oxygenation will be utilized in order to reduce the incidence of hypoxia among obesity.

Condition Colon Cancer, Stomach Cancer, oesophageal cancer, COLONIC POLYP, Colorectal Cancer, Esophageal Cancer, Colon Cancer Screening, Stomach Discomfort, Gastropathy, colon carcinoma, Hypoxia, esophagus cancer, Colon cancer; rectal cancer, Malignant neoplasm of colon, Colon Polyps, gastric cancers, hypoxic, Gastric Cancer, Gastric Carcinoma
Treatment High-Flow Nasal Cannula Oxygenation, Regular nasal cannula
Clinical Study IdentifierNCT04500392
SponsorRenJi Hospital
Last Modified on27 September 2021


Yes No Not Sure

Inclusion Criteria

patients undergoing gastrointestinal endoscopes
age18 years old and 70 years old
patients or family members signed informed consent form
ASA classification I-II
BMI 28kg/m

Exclusion Criteria

Coagulation disorders or a tendency of nose bleeding
An episode/exacerbation of congestive heart failure (CHF) that requires a change in medication, diet or hospitalization from any cause in the last 6 months
Severe aortic stenosis or mitral stenosis
Cardiac surgery involving thoracotomy (e.g., coronary artery bypass graft (CABG), valve replacement surgery) in the last 6 months
Acute myocardial infarction in the last 6 months
Acute arrhythmia (including any tachycardia - or bradycardia) with the fluid of hemodynamics instability
Diagnosed chronic obstructive pulmonary disease or current other acute or chronic lung disease requiring supplemental chronic or intermittent oxygen therapy)
Increased intracranial pressure
ASA classification -
Mouth, nose, or throat infection
Liver and kidney disease
Fever, defined as core body temperature > 37.5
Pregnancy, breastfeeding or positive pregnancy test
Emergency procedure
Patients or family members refused to participate
Mental disorders and people without civil capacity
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