Impact of Aminoglycosides in Hypotensive Septic Oncology Patients

  • STATUS
    Recruiting
  • End date
    Jul 2, 2022
  • participants needed
    319
  • sponsor
    M.D. Anderson Cancer Center
Updated on 23 September 2021
antibiotics

Summary

This study evaluates the impact of aminoglycosides in hypotensive septic oncologic patients. In the oncologic patient population, sepsis is a major health concern due to high mortality rates and healthcare costs. Prior research shows aminoglycosides antibiotics are frequently used to treat sepsis, but their clinical impact in hypotensive oncology patients upon the progression of sepsis is not known.

Description

PRIMARY OBJECTIVE:

I. To assess the impact of beta-lactam (BL) + aminoglycoside (AG) combination therapy in hypotensive septic oncology patients.

OUTLINE

Patients' medical charts are reviewed retrospectively.

Details
Condition systemic infection, systemic infections, Malignant Solid Neoplasm, hematopoietic malignancy, Hematologic Neoplasms, Sepsis and Septicemia, Septicemia, Malignant Solid Tumor, Hematologic Cancer, hematopoietic and lymphoid cell neoplasm, sepsis syndrome, Hematologic Malignancy, Blood Cancer, sepsis
Treatment Electronic Health Record Review
Clinical Study IdentifierNCT05045963
SponsorM.D. Anderson Cancer Center
Last Modified on23 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Adult patients (age >= 18 years) with a diagnosis of sepsis during the index hospital admission identified by International classification of diseases (ICD)-10 codes (as specified below) receiving BL antibiotics within 6 hours prior to or following the onset of hypotension
To be included in the AG group, patients must have received at least 1 dose of intravenous (IV) tobramycin or amikacin in addition to the BL therapy within the above time period

Exclusion Criteria

Age < 18 years
Receipt of IV AG outside of the above time frame in the AG group or receipt of IV AG within 48 hours prior to or following the onset of hypotension in the BL backbone group
Pregnancy
Patients not receiving therapy with BL antibiotics
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