Catch me if You Can - the Individual Relationship Between Potential Ablation Targets From CARTOFINDER and Myocardial Fibrosis

  • End date
    Mar 1, 2023
  • participants needed
  • sponsor
    Heart and Diabetes Center North-Rhine Westfalia
Updated on 19 September 2021
persistent atrial fibrillation


Single center observational study to compare the relationship between atrial fibrosis and potential ablation targets from CARTOFINDER.


A total number of 30 patients will undergo catheter Ablation for persistent AF. Pre-procedural cardiac MRI will be performed with late-gadolinium enhancement to visualize the individual amount and distribution of fibrosis in the right and left atrium. CARTOFINDER-guided mapping will be performed during the ablation procedure followed by AF ablation. The individual relationship between atrial fibrosis and potential ablation targets will be accessed.

Condition Atrial Fibrillation (Pediatric), Dysrhythmia, Atrial Fibrillation, Arrhythmia
Clinical Study IdentifierNCT04586881
SponsorHeart and Diabetes Center North-Rhine Westfalia
Last Modified on19 September 2021


Yes No Not Sure

Inclusion Criteria

Patients undergoing their 1st AF ablation procedure for persistent atrial fibrillation (AF) as per recent Heart Rhythm Society (HRS) consensus document
Able to understand and willing to sign the Informed Consent Form
Age 18 years

Exclusion Criteria

Contraindication for DE-MRI with a full dose of Gadolinium-based contrast agent
Previous left atrial ablation or surgical procedure
Renal failure with CrCl <60 ml/min
Women currently pregnant, breastfeeding, or of childbearing age not currently taking or not willing to use a reliable form of contraception
Mental or physical inability to take part in the study
Uncontrolled hypertension
Morbid obesity (BMI > 35), or inability to be placed in MRI due to body mass
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