Can we Rely on HLA to Predict Resistance to Biological Therapy in IBD Patients

  • End date
    Jul 1, 2024
  • participants needed
  • sponsor
    Centro Hospitalar Tondela-Viseu
Updated on 27 September 2021
tumor necrosis factor


The investigators propose an observational study including patients with inflammatory bowel disease under biological therapy with anti-TNF, anti-integrin or anti-interleukin 12-23 (Ustekinumab), followed by an external Gastroenterology consultation at Centro Hospitalar Tondela-Viseu.

Condition Inflammatory Bowel Disease, Inflammatory bowel disease, Intestinal Diseases, Bowel Dysfunction, Gastroenteritis, inflammatory bowel diseases
Treatment HLA-DQA1*05 and DRB1
Clinical Study IdentifierNCT05040854
SponsorCentro Hospitalar Tondela-Viseu
Last Modified on27 September 2021


Yes No Not Sure

Inclusion Criteria

Patients with the diagnosis of IBD (according to ECCO diagnosis criteria)
Adult patients (over 18 years)
Full capability of signing informed consent

Exclusion Criteria

Patients who refuse to participate in the study
Patients submitted to prior biological therapy (only for the IBD-naive group)
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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