Risk Factors for Acute Kidney Injury in Critically Ill Patients With Acute-on-Chronic Liver Failure

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    200
  • sponsor
    Institutul Clinic Fundeni
Updated on 23 September 2021

Summary

Acute kidney injury (AKI) is one of the most important factors associated with increased mortality in patients with acute-on-chronic liver failure (AoCLF). Early identification and treatment of this subgroup of patients may improve survival and decrease ICU length of stay. As kidney ischemia is one of the main mechanisms responsible for AKI in AoCLF, an increase in urinary to arterial partial pressure of oxygen may help in the early diagnosis of renal failure. For this arterial and urinary oxygen pressure will be measured at ICU admission, on day 1 and day 3 of ICU stay. Diagnosis of AKI within the first 28 days after ICU admission will be recorded

Details
Condition Renal Failure, Acute renal failure, Acute on Chronic Liver Failure, acute kidney injury, acute kidney injuries
Clinical Study IdentifierNCT04525625
SponsorInstitutul Clinic Fundeni
Last Modified on23 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

patients admitted to the ICU for acute-on-chronic liver failure

Exclusion Criteria

pre-existing renal disease
urine output<200 mL/day
death within the first 24 hours after ICU admission
emergency liver transplantation within the follow-up period (28 days)
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