Cardiac MRI for Detection of Acute and Chronic Cardiac Involvement in Patients With Epilepsy

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    University Hospital, Bonn
Updated on 21 September 2021
cardiac mri


The aim of the study is to use multiparametric cardiac MRI to identify any abnormalities in myocardial structure and function in patients with epilepsy. A two-stage study design is planned as part of the study:

  1. In the acute setting, cardiac MRI will be performed in patients before and after a tonic-clonic seizure and compared intraindividually. In this study arm, potential acute seizure-induced myocardial damage will be detected.
  2. In the chronic setting, cardiac MRI will be performed in patients with known chronic epilepsy during the seizure-free interval to detect potential chronic myocardial damage (myocardial fibrosis) and compared with a control population. Within the group of epilepsy patients, possible associations with various epilepsy-specific characteristics (e.g., form, cause, onset, duration, and severity of epilepsy) will be investigated.

Condition Cardiomyopathy, epilepsia, Seizure Disorders (Pediatric), cardiomyopathies, Epilepsy, Heart disease, Cardiac Disease, Seizure Disorders, myocardial diseases, Heart Disease, epileptic, epileptics, seizure disorder
Treatment Cardiac Magnetic Resonance Scan
Clinical Study IdentifierNCT05041296
SponsorUniversity Hospital, Bonn
Last Modified on21 September 2021


Yes No Not Sure

Inclusion Criteria

diagnosed epilepsy
examination under usual antiepileptic pharmacotherapy or medication up-dosing (if medication was reduced during video-EEG recording)
age between 18-60 years

Exclusion Criteria

underlying cardiac disease, e.g. coronary artery disease, previous myocardial infarction, previous myocarditis, complex congenital heart defect, known cardiomyopathy of other cause
pregnant and breastfeeding women
patients who use IUD for contraception
patients with a contraindication to contrast enhanced MRI
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