Study on the Relationship Between Neutrophil-mediated Thrombocytopenia and the Condition and the Course of Disease in Patients With HFRS

  • End date
    Feb 28, 2024
  • participants needed
  • sponsor
    First Affiliated Hospital Xi'an Jiaotong University
Updated on 16 September 2021


Thrombocytopenia is an important pathological feature of HFRSHemorrhagic Fever With Renal Syndrome, HFRS. However, the cause of thrombocytopenia in HFRS is not yet fully understood. Neutrophils, as the largest number of white blood cells in the human body, can widely participate in the immune process of viral infections. Previous studies have found that the neutrophils of patients with acute myocardial infarction can interact with activated platelets and further mediate platelet phagocytosis.Therefore, this study aims to systematically elucidate the immunological process of neutrophil mediated thrombocytopenia in patients with HFRS by exploring the correlation between platelet activation, neutrophil activation and neutrophil proportion of adherent / phagocytic platelets peripheral blood of HFRS patients, and to analyze its relationship with the course of HFRS disease, which lays a theoretical foundation for further understanding the pathogenesis of HFRS and provides a basis for clinical use.

Condition Hemorrhagic Fever with Renal Syndrome
Treatment clinical classification of HFRS
Clinical Study IdentifierNCT04834713
SponsorFirst Affiliated Hospital Xi'an Jiaotong University
Last Modified on16 September 2021


Yes No Not Sure

Inclusion Criteria

Age 18 years
Clinical diagnosis meets the diagnostic criteria of the national HFRS prevention and treatment plan (Hantavirus-specific IgM antibody is positive). The classification and staging standards of HFRS patients are based on the "Expert Consensus of Shaanxi Province on Diagnosis and Treatment of Hemorrhagic Fever with Renal Syndrome

Exclusion Criteria

Age <18 years
Have a history of kidney disease
Have a history of liver disease
Have a history of malignant tumor
Receive dialysis treatment before admission
Combined with hypertension, coronary heart disease and diabetes history
Combined with HIV infection and patients with autoimmune diseases and pregnancy
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