European Study of Cerebral Aspergillosis Treated With Isavuconazole

  • days left to enroll
  • participants needed
  • sponsor
    Imagine Institute
Updated on 20 September 2021


Study clinical context Cerebral aspergillosis (CA) is a rare location of invasive aspergillosis (IA), associated with a high morbidity and mortality. Since 2002, voriconazole is the recommended first line treatment of invasive aspergillosis. More recently, isavuconazole appeared to be not less effective than voriconazole in the treatment of filamentous IFI, with a better tolerance profile.

The investigators aim to evaluate better the efficacy and the safety of isavuconazole in the treatment of cerebral aspergillosis by a descriptive, multicentric, international retrospective cohort study.

Condition Invasive Aspergillosis, Cerebral Aspergillosis
Clinical Study IdentifierNCT04486885
SponsorImagine Institute
Last Modified on20 September 2021


Yes No Not Sure

Inclusion Criteria

Proven or probable cerebral aspergillosis according to the EORTC criteria modified by adding diabetes in the host criteria
In child or adult
Treated by isavuconazole at least 7 days
Diagnosed between March 2017 and June 2020

Exclusion Criteria

Possible cerebral aspergillosis
isavuconazole treatment for less than 7 days
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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