Biobank for Inflammatory Chronic Diseases and Osteoporosis

  • STATUS
    Recruiting
  • End date
    Sep 1, 2031
  • participants needed
    2000
  • sponsor
    University Hospital, Toulouse
Updated on 26 September 2021
osteoporosis
arthritis
rheumatism
rheumatoid arthritis
psoriatic arthritis
secondary osteoporosis

Summary

The aim of this study is to constitute a biobank for patients followed in the Rheumatology center of Toulouse University Hospital for a chronic inflammatory rheumatism including rheumatoid arthritis (RA), spondyloarthritis(SpA), and psoriatic arthritis (PsA) or a chronic bone disease including osteoporosis in order to identify biomarkers associated with therapeutic response.

Description

Biologic ant targeted synthetic disease modifying anti-rheumatic drugs (bDMARDs and tsDMARDs) have greatly improved the prognosis of chronic inflammatory diseases. To date, many bDMARDs and tsDMARDs targeting different immunologic mechanisms are available to treat RA, SpA or PsA. However, the choice of the treatment and its mechanism of action is based on physician decision and experience. Indeed, predictive clinical and biological factors associated with therapeutic response that could help the physician to make his/her choice are lacking. The aim of BIO-TOUL is to collect and store biologic samples in patients with RA, SpA or PsA who begin a new bDMARD or tsDMARD. This biobank will permit to study several biomarkers and assess the association between such markers and response to therapy.

Furthermore, osteoporosis is a chronic disease leading to fractures and disability. Several ant-osteoporotic drugs are now available and biomarker(s) that would help the physician to choose the best therapeutic sequence are lacking. BIO-TOUL will also include patients with osteoporosis to identify biomarkers associated with severity and response to anti-osteoporotic treatments.

Details
Condition Osteopenia, Psoriasis, Osteoporosis, PSORIATIC ARTHRITIS, Rheumatoid Arthritis, Spondylarthritis, Spondyloarthropathy, Arthritis, spondyloarthritis
Treatment blood sampling
Clinical Study IdentifierNCT05039216
SponsorUniversity Hospital, Toulouse
Last Modified on26 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Chronic inflammatory rheumatism including RA, SpA or PsA or patients with primary or secondary osteoporosis
Aged > 18 ans
With National Health Assurance
Able to consent to the study

Exclusion Criteria

Pregnancy or breastfeeding
Not able to give a consent
Severe anemia (Hb<10g/L)
Clear my responses

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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