Peripheral Artery Disease (PAD) : Its Effects on Bone

  • STATUS
    Recruiting
  • End date
    Sep 12, 2022
  • participants needed
    200
  • sponsor
    Centre Hospitalier Régional d'Orléans
Updated on 12 September 2021

Summary

Prevalence of PAD and osteoporosis (OP) both get higher with age. Clinical and epidemiologic evidence have showed an increased cardiovascular risk in OP and bone loss and fragility fractures in patient with cardiovascular disease.

This study will examine the relationship between vascular disease in legs and sBMD and vBMD at trabecular and cortical sites and bone microarchitecture.

Description

The primary goal of our study is to determinate if presence of PAD is associated with lower sBMD and vBMD values at the tibias, assuming that BMD should be more alterate in the predominant vascular impairement site.

Our secondary objectives are to :

  • determine if severity of PAD quantified by ankle brachial index ABI is associated to a decrease of BMD values defined by T-Score at the left hip, spine and legs, but also with volumetric values, assessed by HRpQCT at the non dominant radius and at both tibias.
  • determine the prevalence of osteoporosis in our population
  • To evaluate the relationships between ;
  • lipids and bone parameters
  • vit D and parathormone with PAD severity
  • levels of physical activity and both vascular and bone impairments

Details
Condition peripheral arterial disease, peripheral artery disease, Peripheral Arterial Disease (PAD), peripheral arterial diseases, Bone
Treatment Assessment of BMD by DXA and HRpQCT
Clinical Study IdentifierNCT05034848
SponsorCentre Hospitalier Régional d'Orléans
Last Modified on12 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

PAD patients defined by an Ankle brachial index < 0.9
Written consent
Patient affiliated with a social security organism

Exclusion Criteria

Age < 18 years
Pregnancy or risk of pregnancy
Patients Under guardianship
Patient with known PAD who had been previously treated by surgery or endovascular pathway
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