The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier

  • STATUS
    Recruiting
  • End date
    Jan 20, 2027
  • participants needed
    15
  • sponsor
    Neurological Associates of West Los Angeles
Updated on 12 September 2021

Summary

The limitation of treating intrinsic brain pathologies has been circumvented with neurosurgical techniques; however, less invasive approaches may be desirable particularly for widespread or multifocal disease and when long term and repetitive administration is required. This study seeks to investigate the efficacy of focused ultrasound.

Patients with either low grade gliomas or neurodegenerative dementias will be evaluated for study candidacy.

There are no immediate benefits for patients who choose to participate; however, the information gained from this study will contribute to the research base and help patients in similar situations in the future.

Description

Treatment of intrinsic brain diseases is challenging because brain barrier (BBB) limits the delivery of drugs, particulates and cellular elements such as stem cells to the central nervous system (CNS). This limitation is often circumvented with neurosurgical techniques, however, less invasive approaches may be desirable particularly for widespread or multifocal disease and when long term and repetitive administration is required.

The diagnosis for the participants will be either low grade gliomas. A baseline fMRI and follow up routine fMRI's will be taken and evaluated for any changes in perfusion. During the scans, The ultrasound placement will last for one hour.

This study seeks to investigate the efficacy of focused ultrasound in opening the blood brain barrier. This physiological effect would have significant clinical applications. The ability to open the blood brain barrier has the potential to revolutionize the delivery of therapeutic agents to the brain, allowing for more localized and efficient delivery. There are no immediate benefits for patients who choose to participate; however, the information gained from this study will contribute to the research base and help patients in similar situations in the future.

Details
Condition Low Grade Glioma of Brain
Treatment Focused Ultrasound
Clinical Study IdentifierNCT04063514
SponsorNeurological Associates of West Los Angeles
Last Modified on12 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Subjects undergoing routine, repetitive MRI scanning for monitoring low grade gliomas
or older

Exclusion Criteria

Cognitive decline with mild cognitive impairment (Clinical Dementia Rating
stage 0.5) through moderate dementia CDR stages 1 and 2
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