INvestigating TELmisartin Study

  • STATUS
    Not Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    40
  • sponsor
    University of Hawaii
Updated on 7 July 2022

Summary

This study will enroll 40 inpatients hospitalized for COVID-19 at Queens' Medical Center. Participants will be randomized 1:1 to Telmisartan (80 mg) vs placebo to be administered orally once daily x 21 days.

Description

The study is intended to assess, in a pilot study, the effect of telmisartan in mitigating the severity of COVID-19 related disease in hospitalized patients. Data on clinical course and lab values will be passively abstracted from Queen's standard of care evaluations on COVID-19 in-patients. Participants will be monitored closely as an outpatient if/when discharged prior to day 21. The only study-specific procedure will be a blood draw of ten (10) cc to be collected for research purposes at entry and at day 4 and day 21 of study for the evaluation of the renin-angiotensin system (RAS) system and for various blood biomarkers of organ function/coagulation, inflammation, leukocyte chemotaxis, tissue remodeling/fibrosis and immune exhaustion.

Details
Condition COVID19
Treatment Placebo, Telmisartan Oral Product
Clinical Study IdentifierNCT04715763
SponsorUniversity of Hawaii
Last Modified on7 July 2022

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