Adapted Physical Activity Effect on Abilities and Quality of Life of Huntington Patients and Relatives During Rehab Stay (HUNT'ACTIV)

  • STATUS
    Recruiting
  • End date
    Feb 7, 2023
  • participants needed
    32
  • sponsor
    Assistance Publique - Hôpitaux de Paris
Updated on 25 January 2022
neurological examination
behavioral problems
cognitive assessment

Summary

Intro

Huntington's disease is a neurodegenerative disease that affects the brain, inducing a dysfunction and death of the middle spiny striatal projection neurons and a progressive alteration of cognitive and motor functions, and psycho-behavioral problems. There is currently no curative treatment but we know hat a multidisciplinary care can optimize the functioning and the quality of life of the patients with Huntington's disease.

A meta-analysis of 18studies indicates that exercise and physical activity can improve motor function, gait speed and balance, and would also improve self-confidence, independence, well-being, reduced apathy and better socialization with family and friends.

Hypothesis/Objective The hypothesis is that the inclusion of a 4 week-program with Adapted Physical Activity (APA) during a rehabilitation stay will improve some motor, cognitive and psycho-behavioral abilities, compared to the control group.

Method

The patients will be randomized into two groups :

The control group will have the "classic" program performed in the standard of care with: kinesitherapy, soft gym, medico-social workshop, cognitive workshop, creative workshop, individual care (rehabilitation, rest, and creation).

The experimental APA group will have in addition of the classic program, 6 APA workshops per week with collective support : Adapted Physical workshops, adapted cycling, therapeutic (horseback/equestrian) riding, cultural or leisure outings, situation tests

For the two groups, at the start of the 4 weeks of rehabilitation program an initial visit will be performed with, as part of this research, a clinical examination, a neurological examination, a dietary consultation, as well as a biological assessment as part of habitual care.

The clinical examination, the neurological examination and the dietary consultation will be performed each week, during the 4 weeks of the program,

At the end of the study, one month after the rehabilitation of the patient, a visit by phone-call will be performed for the patient and his caregiver.

Details
Condition Huntington Disease
Treatment Control, Adapted Physical Activity Program
Clinical Study IdentifierNCT04917133
SponsorAssistance Publique - Hôpitaux de Paris
Last Modified on25 January 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Mid-stage Huntington's disease but with the ability for an autonomous walking for 10 meter
Age 18 years old
Stable medication for at least 4 weeks before the start of the study and a stable diet during the duration of the program. A stable diet means no weight loss up to 2kg in the last month prior to inclusion
Patient who received a complete information and who signed an informed consent for the research (or his/her caregiver if incapacity to sign). Tutor/Guardian who received a complete information and who signed an informed consent for the research if applicable
Affiliated to a social security scheme
Inclusion Criteria for the Caregiver
Person participating in the daily life of the patient
The patient is included in the research
Age 18 years old
Having received a complete information
Non opposition collected by the investigator

Exclusion Criteria

Having a physical or psychiatric condition preventing the completion of the program and assessments
Having a history of additional major neurological disorders such as a stroke or an orthopedic condition limiting mobility
Any difficulty to understand or read French which could possibly invalidate the relevance of the application of questionnaires according to the opinion of the investigator
Addictions, alcohol dependence
Any other neurological, musculoskeletal or cardiovascular disease which could lead to errors in the assessment
Participation to another interventional research or being in the exclusion period following a previous research if applicable
Patient under AME (except if exemption from affiliation)
Exclusion criteria for the Caregiver
Having a physical or psychiatric condition preventing the completion of the program and assessments
Any difficulty to understand or read French which could possibly invalidate the relevance of the application of questionnaires according to the opinion of the investigator
Under tutelage or guardianship
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