Exercise Capacity According to Coronary Microvascular Dysfunction and Body Composition

  • End date
    Mar 10, 2023
  • participants needed
  • sponsor
    Korea University Anam Hospital
Updated on 10 September 2021


The correlation of coronary microvascular function and body composition with cardiopulmonary exercise capacity will be assessed in patients with heart failure with preserved ejection fraction.


We will select the patients with chest pain or ischemic symptoms with non-obstructive coronary artery disease (<50% stenosis) in coronary angiography and preserved ejection fraction (50%) in echocardiography. All patients will undergo body composition analysis and adenosine stress echocardiography with the evaluation of coronary artery blood flow by Doppler echocardiography and maximal oxygen consumption (VO2 max) by cardiopulmonary exercise test. Left ventricular end-diastolic pressure will be assessed during coronary angiography. Coronary flow reserve (CFR) is defined as the ratio of peak to baseline mean diastolic velocity of coronary blood flow. The correlation of CFR and body composition with cardiopulmonary exercise capacity will be assessed.

Condition Heart Failure With Preserved Ejection Fraction
Treatment Adenosine stress echocardiography with the evaluation of coronary artery blood flow
Clinical Study IdentifierNCT04822649
SponsorKorea University Anam Hospital
Last Modified on10 September 2021


Yes No Not Sure

Inclusion Criteria

Age 20 to 80
Typical/atypical chest pain or ischemic symptoms including dyspnea
No significant coronary artery stenosis (>50% stenosis) in coronary angiography or computed tomography
Left ventricular ejection fraction 50%

Exclusion Criteria

More than moderate valvular heart disease
Congenital heart disease
Chronic renal failure (estimated glomerular filtration rate <30 ml/min/1.73m2) or end-stage renal failure undergoing hemodialysis or peritoneal dialysis
Asthma, chronic obstructive pulmonary disease and primary pulmonary hypertension
Receiving anticancer drugs
Vasculitis associated with autoimmune diseases
Patients with difficulty in performing exercise load evaluation (treadmill, bicycle ergometer)
Atrial fibrillation
Atrioventricular block with more than second degrees, symptomatic bradycardia, cryo-node failure syndrome, Wolff-Parkinson-White (WPW) patients
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