Long-term of Remote Ischemic Preconditioning in Patients With Mild Hypertension

  • End date
    Feb 20, 2023
  • participants needed
  • sponsor
    Henan Institute of Cardiovascular Epidemiology
Updated on 6 September 2021
systolic blood pressure
beta blockers
antihypertensive drugs
blood pressure diastolic


According to the latest survey data of China hypertension annual meeting, there are about 300 million patients with hypertension in China, with 10 million new cases of hypertension each year, and there is an obvious trend of younger people. In particular, young and middle-aged people are in a state of mild hypertension for a long time, which causes great pressure on health and medical treatment. At present, the main clinical measures for mild hypertension are to change their eating habits, quit smoking and alcohol, exercise and other lifestyle changes, as well as drug control. For most patients with mild hypertension, drug control is not the best choice. It has been reported that remote ischemic preconditioning (RIPC) may play an effective role in reducing blood pressure .The purpose of this study was to investigate the extent of long-term application of RIPC to reduce blood pressure in patients with mild hypertension.


A total of 200 patients with mild hypertension were enrolled in this study, using the method of open label and parallel grouping; 100 cases in the experimental group and 100 cases in the control group, The experimental group was divided into life intervention + drug group and life intervention + ripc group, with 50 patients in each group. The results of 24-hour ambulatory blood pressure monitoring (ABPM) of the three groups were observed before and 3 months after use, including HR, pulse pressure, 24-hour systolic blood pressure, 24-hour diastolic blood pressure, daytime systolic blood pressure, daytime diastolic blood pressure, nighttime systolic blood pressure and nighttime diastolic blood pressure. The changes of renalase, catecholamine, renin, angiotensin - , aldosterone, RhoA kinase, no, adenosine and bradykinin were observed.

Condition Hypertension, High Blood Pressure (Hypertension), High Blood Pressure (Hypertension - Pediatric), Vascular Diseases, Diabetes and Hypertension, high blood pressure, Elevated Blood Pressure, arterial hypertension
Treatment Lifestyle intervention, remote ischemic preconditioning(RIPC), Antihypertensive drugs, Antihypertensive drugs
Clinical Study IdentifierNCT04753840
SponsorHenan Institute of Cardiovascular Epidemiology
Last Modified on6 September 2021


Yes No Not Sure

Inclusion Criteria

Diagnosed patients with mild hypertension (SBP: 140~159mmHg; DBP: 90~99mmHg)

Exclusion Criteria

Cannot tolerate RIPC
Non-essential hypertension
patients who have uncontrolled severe arrhythmia, diabetes, electrolyte disturbance
patients who have severe organic diseases such acute myocardial infarction, cardiac insufficiency, abnormal renal function, etc
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