Dexmedetpmidine Versus Ketamine for Postoperative Sore Throat in Sinus Surgery

  • STATUS
    Recruiting
  • End date
    Dec 30, 2022
  • participants needed
    120
  • sponsor
    Assiut University
Updated on 23 April 2022
anesthesia
intubation
sore
throat pain

Summary

The aim of this randomized clinical trial is to evaluate the impact of dexmedetomidine versus ketamine soaked pharyngeal packing on postoperative sore throat in functional endoscopic sinus surgery (FESS).

Description

A written informed consent was taken from the patients.patients will be randomly assigned to three groups of 40 subjects each; dexmedetomidine or ketamine or saline soaked pharyngeal packs were situated under direct vision. Throat packs made of gauze with a length of 20 cm and a width of 10 cm (folded transverse four times) and medications were diluted with 20 ml normal saline. The packings were placed by the surgeon blinded to the study groups.

1-Dexmedetomidine group: 75 µg dexmedetomidine soaked pharyngeal pack (Group D) putted in the posterior pharyngeal wall after induction of anesthesia and & endotracheal tube (ETT).

2-Ketamine group: 50 mg ketamine soaked pharyngeal pack (Group K) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

3-Control group: 20 ml 0.9% saline soaked pharyngeal pack (Group C) putted in the posterior pharyngeal wall after induction of anesthesia and ETT.

Details
Condition Sore Throat
Treatment Dexmedetomidine, Ketamine, Saline 0.9%
Clinical Study IdentifierNCT04955158
SponsorAssiut University
Last Modified on23 April 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Adults of both sex with American Society of Anesthesiologists (ASA) physical status I-II
Elective functional endoscopic sinus surgery (FESS) with endotracheal intubation

Exclusion Criteria

A history of preoperative sore throat
Upper respiratory tract illness
Potentially difficult airway
Patients with history of neck, respiratory or digestive tract pathology
Chronic smokers
Using steroid within the last 48 hour
Pregnant women
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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