Tetracycline Versus Doxycycline for HP Rescue Therapy

  • End date
    Dec 30, 2022
  • participants needed
  • sponsor
    Shanghai Zhongshan Hospital
Updated on 3 September 2021


This randomized controlled clinical trial will evaluate the efficacy and safety of proton pump inhibitor, bismuth, metronidazole, and either tetracycline or doxycycline for Helicobacter pylori rescue treatment. The completion of this trial will expand new therapy for the treatment of Helicobacter pylori.

Condition Helicobacter Pylori Infection, H. Pylori Infection
Treatment doxycycline, metronidazole, Rabeprazole, Tetracycline, Bismuth Potassium Citrate
Clinical Study IdentifierNCT05018923
SponsorShanghai Zhongshan Hospital
Last Modified on3 September 2021


Yes No Not Sure

Inclusion Criteria

Participate in the trial voluntarily, fully understand the trial, and sign the informed consent form (ICF)
-75 years old on the day of signing the ICF
Helicobacter pylori infection confirmed by 13C-urea breath test or rapid urease test
Have failed eradication treatment before

Exclusion Criteria

Have not received Hp eradication treatment
Patients with severe heart, lung, kidney, liver, blood, nerve, endocrine, and psychiatric diseases
Subjects or guardians refused to participate in the trial
Alcohol and/or drugs Abuse (addiction or dependence) or poor compliance with doctor's judgment
Have taken antibiotics, bismuth, PPI or Chinese traditional medicine 4 weeks before treatment
Pregnant or lactating women
Active peptic ulcer
allergic to drugs used in the trial
any other circumstances that are not suitable for recruitment
Clear my responses

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Step 1 Connect with a study center
What happens next?
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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