The Impact of WeChat Group Patient Education on the Eradication Rate of Helicobacter Pylori

  • days left to enroll
  • participants needed
  • sponsor
    Shandong University
Updated on 2 September 2021


In this study, effects of oral and written education, WeChat education plus oral and written education on Helicobacter pylori eradication will be compared in a randomized way.


There are two randomized parallel groups in this study, control group and Wechat group.All of the patients will be treated with Amoxicillin + Clarithromycin + Bismuth + Vonoprazan fumarate. In control group,the patients will be educated by oral and written way about the regimen. In Wechat group, the patients will be educated by Wechat oral and written way. Then, the eradication rates, compliance, adverse events, patients' satisfaction and experience will be evaluated.

Condition H. Pylori Infection, Helicobacter Pylori Infection, Helicobacter Pylori Eradication, Patient Education
Treatment wechat group, oral and written education
Clinical Study IdentifierNCT04850209
SponsorShandong University
Last Modified on2 September 2021


Yes No Not Sure

Inclusion Criteria

aged between 18 and 75 years old
H. pylori infection confirmed by any two positive outcomes of rapid urease test (RUT), 13C-urea breath test (UBT) or histopathology

Exclusion Criteria

previous therapy for H. pylori
with significant underlying disease (e.g. decompensated liver cirrhosis, renal failure or malignant tumors) that may interfere the study
history of gastric surgery
pregnancy or lactation
the use of PPI or antibiotics during the 4 weeks prior to enrolment
previous history of allergic reactions to any of the medications used in this protocol
unable to use smartphone and wechat
unwilling or incapable to provide informed consents
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