Comparison Between Ultra-low-dose Computed Tomography and Lung MRI in Cystic Fibrosis (UBD-IRM)

  • STATUS
    Recruiting
  • End date
    Aug 15, 2023
  • participants needed
    200
  • sponsor
    Assistance Publique - Hôpitaux de Paris
Updated on 15 June 2022
fibrosis
diagnostic procedures

Summary

The purpose of this study is to compare the performances of ultra-low dose computed tomography (CT) and lung magnetic resonance imaging (MRI) for morphological assessment of cystic fibrosis-related lung disease and to compare their performances to conventional low dose CT

Description

Cystic fibrosis (CF) is a recessive autosomal disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that encodes for an epithelial chloride channel involved in ion and fluid transport. CF is the most common inherited disease in Caucasians and disease severity mainly depends on the degree of lung involvement, which can lead to terminal respiratory failure Disease monitoring of CF-related lung disease rely on functional assessment and complimentary morphological assessment. Conventional low-dose chest computed tomography (CT) is currently the gold standard for the morphological assessment of CF-related lung disease but ultra-low dose chest CT and high-resolution magnetic resonance imaging (MRI) of the lung using UTE sequences have been recently developed and allow important radiation reduction of radiation dose exposure. However the performances of these 2 competing imaging methods remains to be compared.

Details
Condition Cystic Fibrosis
Treatment lung MRI, CT scanner, CT scanner
Clinical Study IdentifierNCT04644471
SponsorAssistance Publique - Hôpitaux de Paris
Last Modified on15 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age ≥ 18 year-old
Diagnosis of cystic fibrosis provided by genetic and swear test
Chest CT acquisition performed as part of the standard follow-up
Patient with social security or health insurance
Informed consent

Exclusion Criteria

MRI contraindication
Orthopnea
Inability to hold breath for 17 seconds
No spirometry planned the same day
Lung transplant patient
Clear my responses

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