VAC Bioburden Wound Care Assessment

  • STATUS
    Recruiting
  • days left to enroll
    38
  • participants needed
    40
  • sponsor
    Duke University
Updated on 2 September 2021

Summary

The purpose of this study is to compare the microbiologic burden and need for further operative debridement of patients undergoing primary surgical debridement of infected tissue, soft tissue abscesses, or traumatic wounds of the upper and lower extremity.

Description

Bacterial bio-burden as measured by quantitative microbial PCR prior to debridement, immediately following initial debridement, after 2 days of VAC veraflo (or conventional VAC) therapy, and at the time of repeat operative debridements, if needed. We will use the MicroGen PCR platform (DBA Microgen Diagnostics, LLC, Lubbock, TX.) to report on the bacterial burden (reported on a log scale of bacteria per gram) present at the time of debridement. Our goal is to be able to assess the bioburden quantitatively at each time point to discern a change.

Exploratory outcomes to be measured: number of operative debridements required prior to reconstruction, number of days until final reconstruction, number of days until decision is made by surgeon that further debridements are no longer necessary, length of hospital stay, wound surface area will be monitored from enrollment through when the veraflo is removed. This is likely a 3-month interval.

Details
Condition Lower Extremity Wound, Traumatic Wounds, Soft Tissue Abscesses, Upper Extremity Wound
Treatment Wound Vac is applied
Clinical Study IdentifierNCT04826965
SponsorDuke University
Last Modified on2 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

+yo with an injury or infection of the upper or lower extremity for which surgical debridement (in the operating room) followed by VAC application is planned

Exclusion Criteria

Patient with wounds distal to the ankle
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