Protective Effects of Edaravone Dexborneol

  • STATUS
    Recruiting
  • End date
    Mar 31, 2023
  • participants needed
    80
  • sponsor
    Lili Cao
Updated on 22 September 2021

Summary

The patients of acute ischemic stroke were divided into two groups, edaravone dexborneol treatment group and edaravone treatment group. The purpose of this study was to observe the changes of imaging and the improvement of NIHSS and mRS in different groups.

Description

A total of 80 patients with acute ischemic stroke of middle cerebral artery were randomly divided into two groups, edaravone dexborneol treatment group and edaravone treatment group. The mismatch area between the low perfusion area of MRI 3D-ASL and the infarct area of DWI was defined as the ischemic penumbra, and the CBF perfusion pseudo color images with PLD of 1.5s and 2.5s were recorded. The above two CBF perfusion images were subtracted, and the residual area was quantitatively analyzed to reflect the establishment of collateral circulation. We aimed to observe whether there were differences in the improvement of ischemic penumbra and the establishment of collateral circulation between two groups after treatment. Besides, the improvment of NIHSS and mRS was also observed in different periods.

Details
Condition Acute Ischemic Stroke
Treatment edaravone dexborneol or edaravone
Clinical Study IdentifierNCT05024526
SponsorLili Cao
Last Modified on22 September 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Aged from 50 to 80 years old
Patients diagnosed as acute ischemic stroke according to Chinese guidelines for the diagnosis and treatment of acute ischemic stroke 2018 and who met the requirements of middle cerebral artery blood supply area infarction (except deep perforator disease) without treatment
Brain MR showed that the low perfusion area of ASL was at least 20% larger than that of DWI core infarct area, and the contralateral mirror brain tissue was basically normal
NIHSS score was between 4 to 24
Patient or their legal representatives were willing to sign the informed consent form

Exclusion Criteria

Serious mental abnormality, complicated with heart, lung, liver, renal insufficiency or malignant tumor and other serious diseases
Combined with cerebral vascular malformation or cerebral hemorrhage
Pregnant or lactating women
Allergic to edaravone or dexborneol
There are interactions between the drugs being taken by patients and the study drug or affect the clinical trial parameters
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