Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy

  • End date
    Aug 21, 2023
  • participants needed
  • sponsor
    University of Michigan
Updated on 21 March 2022
parathyroid hormones
primary hyperparathyroidism
parathyroid surgery


This study will see if the use of near infrared autofluorescence (NIRAF) detection with an FDA-cleared device 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during parathyroidectomy (PTx) procedures is better than a surgeon's detection alone. It compares risk-benefits and outcomes in PTx patients where NIRAF detection with PTeye for parathyroid identification is either used or not used.

Condition Parathyroid Adenoma, Parathyroid Neoplasms, Parathyroid Cancer, Hypercalcemia, Primary Hyperparathyroidism
Treatment PTeye
Clinical Study IdentifierNCT05022641
SponsorUniversity of Michigan
Last Modified on21 March 2022


Yes No Not Sure

Inclusion Criteria

Primary hyperparathyroidism who will be undergoing parathyroid surgery
Persistent primary hyperparathyroidism after having undergone a failed prior parathyroid surgery who will be undergoing repeat parathyroid surgery

Exclusion Criteria

Pregnant women (Those patients who could potentially will receive preoperative pregnancy testing, as is standard before general anesthesia. Any patients with positive pregnancy test results will not be included in the study.)
Patients with concurrent parathyroid and thyroid disease that require total thyroidectomy
Patients with secondary or tertiary hyperparathyroidism
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