The Prognostic Impact of Selenium On Critical Surgical Patients

  • STATUS
    Recruiting
  • End date
    Oct 27, 2023
  • participants needed
    155
  • sponsor
    Chang Gung Memorial Hospital
Updated on 27 August 2021

Summary

Selenium is an important trace element for human for its multiple roles such as the antioxidant activity. Previous evidences showed that critically ill patients may benefit from selenium supplement but the dose and results are controversial.

Patients after operations for acute abdomen usually suffer from sepsis and stress. The aim of this study is to investigate the efficacy of selenium replacement in critical patients of acute abdomen, to see the impact on prognosis.

Description

Acute abdomen is a common surgical emergency and is often the result of peritonitis due to an acute inflammatory process within abdominal cavity. Many of the patients with acute abdomen have severe sepsis and are critically ill that require an emergency surgery.

The mortality rate of such patients are high because these patients usually have a profound pathophysiological dysregulation and multiple organ dysfunction. One of the mechanism of is the loss of anti-oxidative capacity of cells that fail to recover from ischemic-reperfusion injury.

Selenium is an important cofactor that participate in the antioxidant activity of glutathione peroxidase reaction. There are evidences that critically ill patients may benefit from selenium supplement by better outcome and less mortality but the dose and results are still heterogenous and inconclusive.

The aim of this study is to investigate the efficacy of selenium replacement in critical patients of acute abdomen, to see if there is a significant impact on prognosis, and to establish a clinical guide in the future.

Details
Condition Sepsis and Septicemia, systemic infection, systemic infections, Trace Element Deficiency, critically ill, acute abdomen, sepsis syndrome, Critical Illness, Septicemia, sepsis, Selenium Deficiency
Treatment Normal saline, Selenium Supplement
Clinical Study IdentifierNCT04662242
SponsorChang Gung Memorial Hospital
Last Modified on27 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Intensive care unit (ICU) patients receiving abdominal surgeries for acute abdomen
within 48 hours post-operatively
stay in ICU for more than 48 hours
meets sepsis criteria of Sepsis-3 (2016)

Exclusion Criteria

liver cirrhosis Child-Pugh score B or C
breastfeeding or pregnancy
allergy yo selenium
vegetative status or irreversible diseases with life-expectancy fewer than 28 days
End-stage renal disease under dialysis
Human inmunodeficiency virus infection
neutropenia not due to sepsis (granulocyte < 1000/mm3)
Heart failure (New York Heart Association class III-IV) or recent myocardial infarction (within 6 weeks)
post cardiopulmonary cerebral resuscitation within 4 weeks
taking immunosuppressants
receiving anti-cancer therapy
signed do not resuscitation
joined other clinical research
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